Effect of Camellia sinensis on Fat Peroxidation and Ox-LDL in Rats

Green tea (GT) is believed to have antioxidant properties and beneficial effects on the treatment of some diseases. However, few findings were found concerning the impact of GT on oxidative stress. In the present study, the protective influence of GT against the oxidative stress caused by hydrogen peroxide (H۲O۲) in rats was evaluated. The research groups included a control (Con) group and five groups supplemented with ۱۰g GT(G۱), ۲۰g GT(G۲), ۱% H۲O۲(P), ۱% H۲O۲and۱۰g GT (GP۱), as well as ۱% H۲O۲ and ۲۰g GT(GP۲). The effects of GT and H۲O۲ administration on serum biochemical parameters, such as lipid profile, malondialdehyde (MDA), and oxidized low-density lipoprotein (Ox-LDL) were assessed. The findings of this research revealed that the usage of GT lowered the level of cholesterol, triglyceride, LDL, MDA, Ox-LDL and coronary risk index. Moreover, an increase in high-density lipoprotein and very-low-density lipoprotein (VLDL) was observed in subjects who received GT, compared to the rats of the P group. The baseline lipid profile and GT consumption with or without H۲O۲ were the same between the Con and GT-treated groups. Therefore, GT usage was found to be advantageous in reducing Ox-LDL and lipid peroxidation in rats. These results confirm the traditionally claimed benefits of GT for protection against lipid peroxidation and atherosclerosis.

کلیدواژه ها:

Camellia sinensis ، green tea ، Lipid peroxidation ، OX-LDL ، rat