Potential Ameliorative Effect of Artemisia Absinthium Supplement against Sodium Fluoride-Induced Prostatic Toxicity in Rats
محل انتشار: مجله آرشیو رازی، دوره: 77، شماره: 2
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 57
فایل این مقاله در 7 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_ARCHRAZI-77-2_048
تاریخ نمایه سازی: 6 دی 1402
چکیده مقاله:
Prostate dysfunction is the most common condition among aged men, which causes adverse complications and may result in serious diseases. Artemisia has been studied since time immemorial in several studies all showing its ability in preventing and treating different diseases. However, so far there have been no studies focusing on the possible role of Artemisia in the protection of prostate histoarchitecture toxicity. Therefore, this study aimed to investigate the protective role of Artemisia in the amelioration of histological and hormonal depression affected by sodium fluoride (NaF). A total of ۲۸ male adult Wistar rats were equally divided into four groups (n=۷). Animals in the control group received normal saline. The second group received NaF by oral gavage at a dose of ۱۲ mg/kg body weight (B.W.) three times a week. The third group received concurrent treatment with NaF at a dose of ۱۲ mg/kg B.W. three times a week, as well as extraction of Artemisia absinthium at a dose of ۱۰۰ mg/kg B.W. The fourth group was treated only with extraction of Artemisia absinthium at a dose of ۱۰۰ mg/k B.W. After ۶۰ days, B.W. and the absolute weight of the prostate were measured. Blood samples and tissues were collected for measuring testosterone, follicle-stimulating hormone, as well as luteinizing hormone concentration, conducting paraffin-embedded sections with hematoxylin, and eosin routine staining. The findings revealed that Artemisia supplement significantly increased body and absolute weight of prostate gland in the group treated by NaF. In addition, mitigating the histological changes throughout the restoration of all prostate components appeared nearly as normal structural tissue. Moreover, the height of glandular epithelium decreased, follicular lumen enlarged, dark secretion materials with homogeneity disappeared of invagination intraluminal, and normal stroma appeared in regular shape. All in all, the results of this study pointed out that Artemisia had a protective effect against NaF-influenced prostate toxicity via stabilizing male hormones, re-composing histoarchitecture, and returning abnormal biomorphic parameters to a nearly normal state.
کلیدواژه ها:
نویسندگان
H Shakir Saleh
Biology Department, College of Education for Pure Science, University of Thi-Qar, Nasiriyah, Iraq
S Yahya Kraidi
Pharmacology Department, College of Pharmacy, Al-Muthanna University, Samawah, Iraq
W Ali Mahdi
College of Pharmacy, University OF Kerbala, Kerbala, Iraq
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :