Evaluating the Level of Serum IL-۲۳ in Brucellosis Infection by ELISA and Investigating its Relationship in Cases with Failure to Respond to Treatment

Brucella is belonging to the small immobile gram-negative spore-lacking cocco-bacilli bacteria family that grows in an aerobic environment, it is known as a zoonosis infection named brucellosis. This study was designed to investigate serum values of IL-۲۳ in patient with brucellosis and investigate its relationship with cases with failure to respond to conventional medical therapy. A total of ۳۷۲ individuals were divided into ۲ groups (n=۱۸۶) as follows: Group A comprising ۱۸۶ infected participants with brucella (۷-۸۰ years-old), these people had not received antibiotics for at least ۶ months ago. Group B including the healthy participants. All the participants in both groups were in the same age range. ۵ ml blood samples were obtained from the participants intravenously (without anticoagulation substance). The serum level of IL-۲۳ was investigated by ELISA diagnostic kit. The recorded data showed that the levels of IL-۲۳ in the serum samples obtained from group A (۱۴۳.۶۴ Pg/ml) significantly (P<۰.۰۰۱) increased compared with this value in group B (۲۳.۱۴ Pg/ml). Based on the recorded data in the forms completed by all the participants at the day ۰ of the experiment, ۴۴ out of ۱۸۶ individuals in group A, had experienced Brucellosis attack ۲-۳ times in spite of receiving medical prescriptions. A hypothesis about the possible immune system disorders in these participants lead us to did the re-sampling following drug administration. Results illustrated failure to respond to conventional medical therapy in patients with low level of serum IL-۲۳.

کلیدواژه ها:

IL-۲۳ ، Serum value ، Brucellosis ، Medical therapy