Association between Atherogenic Index and Cholesterol to HDL Ratio in COVID-۱۹ Patients During the Initial Phase of Infection
محل انتشار: مجله آرشیو رازی، دوره: 77، شماره: 3
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 105
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شناسه ملی سند علمی:
JR_ARCHRAZI-77-3_048
تاریخ نمایه سازی: 6 دی 1402
چکیده مقاله:
This case-control study aimed to assess pathologic alteration in the serum levels of the atherogenic index, cholesterol to high-density lipoprotein (HDL) ratio, HDL cholesterol, total cholesterol, triglyceride, HbA۱c, and glucose in ۱۵۸ COVID-۱۹ patients who were hospitalized in Erbil international hospital, Erbil, Iraq, between January and May ۲۰۲۰, in the early stage of infection. The patients were confirmed for SARS-CoV-۲ on admission. The laboratory test results were compared between this group and a group of healthy individuals (n=۱۵۸). A statistically significant difference was found between the studied factors in healthy controls and COVID-۱۹ patients, except for low-density lipoprotein (LDL) cholesterol (P=۰.۱۳). In the case of COVID-۱۹ patients, total levels of cholesterol and HDL cholesterol were significantly lower than controls (P<۰.۰۰۳). Triglyceride, VLDL cholesterol, atherogenic index, and total cholesterol to HDL ratio were found to be significantly higher in COVID-۱۹ patients, compared to controls (P<۰.۰۰۵). Atherogenic index were found to be positively correlated with triglyceride (r=۰.۸۸, P=۰.۰۰), HbA۱C (r=۰.۶, P=۰.۰۵), and glucose index (r= ۰.۶۲, P= ۰.۰۵), and the ratio of cholesterol to HDL (r=۰.۶۴, P=۰.۰۴). In contrast, no correlation was found between atherogenic index and cholesterol to HDL ratio in controls. The results of the current study indicated that risk factors for the cardiovascular disease increased in patients with COVID-۱۹ infection, which included atherogenic index, cholesterol to HDL ratio, as well as the association between atherogenic index, and all were organized in one cluster. Therefore, lipids can perform a vital physiological function in patients infected with COVID-۱۹.
کلیدواژه ها:
نویسندگان
E. M Taha
Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq
M Mohialdeen Taha
Kirkuk University, Erbil International Hospital, Kirkuk, Iraq
S. K Al-Obaidy
University of Baghdad, College of Agriculture, Baghdad, Iraq
B Faris Hasan
Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq
S. M Rahim
Kirkuk University, Kirkuk, Iraq
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