Establishment of Reference Intervals for Renal Function Clinical Chemistry Parameters in an Indonesian Tertiary Hospital

Reference intervals aid clinical decision-making for clinical chemistry values. Laboratory test results are compared to reference intervals to aid in the diagnosis, therapy, and monitoring decisions. Due to the differences in ethnicity, gender, age, and analytical methods, reference intervals (RIs) vary between populations. This study aimed to establish the reference values for renal function tests in targeted populations in Indonesia. This research was conducted with a cross-sectional observational analytic design. The research sample consisted of medical check-up data from health professionals at Dr. Mohammad Hoesin Hospital in Palembang, Indonesia. The Kolmogorov-Smirnov test was used to determine the normality of data distribution.  The RIs were computed using reference limits at the ۲.۵th and ۹۷.۵th percentiles (abnormal distribution) or ±two standard deviations (±۲ SD) (normal distribution). The independent t-test (parametric) or Mann-Whitney test was used to compare the RIs of males and females (non-parametric). Males and females had a significant difference (P<۰.۰۰۱) regarding the values of uric acid, urea, and creatinine parameters, requiring the reference intervals to be separated. The following reference intervals were established: uric acid: ۲۳۰,۷۸-۵۲۶,۹۹ mol/L for males and ۱۷۹,۰۳-۴۱۵.۱۷ mol/L for females, urea: ۲,۲۲-۴,۹۹ mmol/L for males and ۱,۷۸-۴,۲۸ mmol/L for females, and creatinine: ۶۱,۰۱-۱۰۶,۹۹ mol/L for males and ۴۰,۶۷-۷۷,۸۱ mol/L for females. This study defined gender-specific RIs for three renal function test parameters for the adult population of Palembang, Indonesia. The deployment of population-specific RIs may facilitate better laboratory testing.

کلیدواژه ها:

Clinical laboratory ، kidney function tests ، reference values