The Association of Serum Calcium and Vitamin D with Insulin Resistance and Beta-Cell Dysfunction among People with Type ۲ Diabetes

Cross-sectional studies have linked vitamin D deficiency and alteration of calcium levels to an increased incidence of type ۲ diabetes and insulin resistance. This study investigated a possible correlation between blood vitamin D and calcium levels with insulin resistance and beta-cell dysfunction in type ۲ diabetes, pre-diabetes, and healthy individuals. This cross-sectional study involved ۳۰۰ participants. Participants were divided into three groups (n=۱۰۰), type ۲diabetic, prediabetic, and healthy. In order to measure insulin resistance and β –cell function, the HOMA IR and HOMA B were assessed, respectively. Also, the other parameters such as serum ۲۵(OH)D, blood insulin (FPI), glucose (FBS), HbA۱c, and calcium were assessed in this study. In simple regression analysis, a high vitamin D level is linked to lower levels of FBS, HbA۱c, Insulin, and HOMA IR, and higher levels of HOMA B. Calcium has a positive connection with FBS and HbA۱c and a negative connection with insulin level and HOMAB. Hypovitaminosis D may substantially influence diabetes patients' glycemic dysregulation. "An increased incidence of type ۲ diabetes has been related to a disruption in calcium homeostasis. All in all an increament in calcium levels may have a role in developing type ۲ diabetes".

کلیدواژه ها:

Type ۲M ، ۲۵ (OH) D ، calcium ، vitamin D deficiency ، Insulin resistance ، Glycemic control