Serum Level of Heat Shock Protein ۷۰ in Patients with Type ۲ Diabetes Mellitus in Basrah, Iraq

Diabetes mellitus is a chronic metabolic disease with an increasing prevalence, caused by a defect in insulin production, insulin action, or both, and can increase the risk for the development of microvascular as well as macrovascular complications. Heat shock protein۷۰ is considered a family of a larger group of proteins known as heat shock proteins, which their expression is induced when the cells are subjected to environmental stress. They are believed to keep the native folding of proteins in cells under stressful conditions and their therapeutic role. Therefore, this study aimed to investigate the serum level of HSP۷۰ in patients with type ۲ diabetes mellitus (T۲DM) to assess if there is an association of HSP۷۰ with T۲DM and to evaluate the effect of age and duration of disease on the serum level of HSP۷۰. Ninety-one patients with T۲DM were recruited, and ۸۵ individuals with the same age range and sex as healthy controls. Serum HSP۷۰, fasting blood sugar, and HbA۱c were measured. The results revealed that the level of HSP۷۰ was significantly higher in the diabetic group compared to the control group (P value<۰.۰۵). The level of HSP۷۰ showed a significant positive correlation with age and duration of disease as well as with fasting blood sugar and HbA۱c. The study suggested that HSP۷۰ may have the potential to be used as an indicator of metabolic derangement and a prognostic biomarker in diabetes.

کلیدواژه ها:

type ۲ diabetes mellitus ، HSP۷۰ ، Fasting blood sugar ، Glycated hemoglobin ، Duration of DM