High-intensity interval training combined with saffron supplementation modulates stress-inflammatory markers in obese women with type ۲ diabetes

Introduction: The aim of this study was to investigate the interactive effects of saffron extract supplementation with high-intensity interval training (HIIT) on serum levels of stress-inflammatory markers in obese women with type ۲ diabetes.Method: Thirty-two obese women with type ۲ diabetes were randomly divided into ۴ intervention groups: supplement, HIIT +Supplement, placebo and placebo+ HIIT. The anthropometric and blood characteristics of subjects were evaluated in pre-test and post-test. The method of supplementation was that the supplement group received ۱۰۰ mg of saffron extract daily. The subjects in the training group also did running on the treadmill in ۴ bouts with intensity of ۸۵ to ۹۵% of the maximum heart rate along with ۴ periods of active rest at the intensity of ۵۰ to ۶۰% of the maximum heart rate.Results: Data analysis showed that the effect of time was a significant decrease in serum levels of IL-۶, NT-proBNP and GDF-۱۵ in the supplement, supplement+ HIIT and placebo+ HIIT groups (P≤۰.۰۵). The results of time × group interaction also showed a significant difference between the groups (P≤۰.۰۵). So that the decrease in the levels of stress-inflammatory markers in the supplement+ HIIT group had a greater decrease.Conclusion: According to the results, it can be reported that HIIT and saffron supplementation (combination of both) probably reduces the levels of stress-inflammatory markers such as GDF-۱۵, NT-proBNP and IL-۶ by reducing fat mass, as well as also improve glucose metabolism and insulin resistance in obese women with diabetes.

کلیدواژه ها:

Growth differentiation factor-۱۵ ، interleukin-۶ ، NT-proBNP ، inflammation ، type ۲ diabetes