Theoretical Electrochemical Study and Free Energies of Electron transfer of Serotonin with Fullerenes C۶۶ Nanostructurs Complexes

Serotonin receptors are involved in the regulation of a diverse group of physiological signalling pathways from the G protein family (GPCRs) or ligand-gated ion channels. It seems that serotonergic signals play an important role in the production and regulation of various cognitive functions and behaviours such as sleep, mood, pain, anxiety, depression, aggression and learning. In this study, the number of carbon atoms in fullerenes was used as descriptors to establish a good relationship between the structure of Serotonin and Fullerenes Cn (n= ۶۶, ۰۶, ۰۶, ۲۲ and ۲۶). The first to fourth free activation energies of electron transfer and kinetic rate constant of the electron-transfer, ΔGet(n)# and ket(n), n=۱-۴ , respectively were calculated in this study for Serotonin with Fulleren Cn complexes with used calculated of four free energies of electron-transferGet(n) # ( Get(۱) # to Get(۴) #), of this supramolecular complexes. This calculation agrees with the Marcus theory.

کلیدواژه ها:

Fullerenes ، Serotonin ، Free energies of electron transfer ، Rate constants