The study of dose gamma rays of ۱۹۲Ir source on DNA single strand break (SSB) and DNA double strand break (DSB) in soft tissue phantom

Introduction: Passage of ionizing radiation through the organs of living creatures develops clusters of damaged nucleotides inside the DNA rounds. ۱۹۲Ir Gamma source is one of the most widely used sources in brachytherapy of cervical and prostate cancer. Thus, in this research, we investigated the flux of photons and its resulting secondary electrons, the single-strand break (SSB) and double-strand break (DSB) that these electrons develop in the molecule DNA, and the dose rate in dimensions of DNA at different distances off the source in a soft tissue spherical phantom. Materials and Methods: In this research, using Code MCNPX, we defined a soft tissue spherical phantom, where iridium ۱۹۲Ir gamma source was placed in its center with ۱۳ spherical cells with a radius of ۳۰μm at distances off the mean free path multiplier of the average energy of this source. In the center of each of the ۱۳ cells, cylinders with a radius of ۱۰۰nm and height of ۳۰۰nm were considered as approximate dimensions of the molecule DNA. Next, using this code, we calculated the flux and dose inside the cylinders. Furthermore, through the obtained electron flux, we obtained the efficiency of DNA single-strand break and double-strand break using Monte Carlo Damage Simulation (MCDS) Code. Results: The data indicated that as the distance from the source increased, the flux of photons and electrons decreased due to interaction with the environment. Thus, the dose rate values for this source with the assumptive activity of ۱mci inside the cylinders with dimensions of DNA at distances of ۰.۰۴, ۰.۰۴۶, ۰.۰۵۲, ۰.۰۵۸, ۰.۰۶۴, ۰.۰۷, ۰.۰۷۶, ۰.۱, ۰.۵, ۱, ۱.۵, ۲, ۲.۵ cm (the cells lie within these distances) were ۷.۵۶, ۵.۶۶, ۴.۳۶, ۳.۳۹, ۲.۶۵, ۲.۰۶, ۱.۶۳, ۰.۸۵, ۲.۸×۱۰-۲, ۷.۳۵×۱۰-۳, ۳.۵۸×۱۰-۳, ۲.۰۶×۱۰-۳, ۱.۴۱×۱۰-۳  μGy/s, respectively. Furthermore, the probability of single-strand break(SSB) and double-strand break(DSB) also decrease due to lower flux of electrons at farther distances. It had the maximum probability in ۲.۵cm of ۰.۲% and ۰.۰۰۹% in single-strand and double-strand damages, respectively. Conclusion: The results suggested that in addition to the interaction between rays and the environment and occurrence of photoelectric, Campton, and pair production, the energy of the source photons decreased, and secondary electrons were generated. Electrons are the main cause of development of break in the molecule DNA. In this regard, as the data indicated, at the farthest distance, electron flux still existed in the cylinders with dimensions of DNA, causing damage. Thus, investigation of the breaks of strand DNA and the dose resulting from the ۱۹۲Ir source is important and should be taken into account in brachytherapy in order to prevent its delayed effect after the treatment.

کلیدواژه ها:

MCNPX Code ، MCDS Code ، Double-Strandbreak (DSB) ، Single-Strand Break (SSB) ، Dosimetry