Iron-gold (Fe۲O۳@Au) core-shell nano-theranostic for magnetically targeted photothermal therapy under magnetic resonance imaging guidance

Introduction: Photothermal therapy (PTT) is a nanotechnology-assisted cancer hyperthermia approach in which the interaction between laser light and plasmonic nanoparticles generates a localized heating for thermoablation of the tumor. Recent efforts in the area of PTT follow two important aims: (i) exploitation of targeting strategies for preferential accumulation of plasmonic nanoparticles within the tumor and (ii) enabling real-time guidance of PTT operation through employing multimodal imaging modalities. Materials and Methods: In the present study, we utilized a multifunctional theranostic nanoplatform constructed from a magnetic core and Au shell (Fe۲O۳@Au) in order to fulfill these aims. The Au shell exhibits surface plasmon resonance, a property that is exploited to realize PTT. The magnetic core enables Fe۲O۳@Au to be used as magnetic resonance imaging (MRI) contrast agent. Furthermore, the magnetic core can also be used to achieve a magnetic drug targeting strategy through which Fe۲O۳@Au would be concentrated in the tumor site by means of magnetic field. Balb/c mice bearing CT۲۶ colorectal tumor model were intraperitoneally injected with Fe۲O۳@Au. Immediately after injection, a magnet (magnetic field strength of ۰.۴ Tesla) was placed on the tumor site for ۶ hours in order to concentrate Fe۲O۳@Au, and thereafter the tumors were irradiated with the near infrared (NIR) laser source (۸۰۸ nm; ۲ W/cm۲; ۳ min). This experiment was conducted for three sessions. Results: MRI confirmed the accumulation of nanoparticles within the tumor due to T۲ enhancement capability of Fe۲O۳@Au. The temperature of the tumors without magnetic targeting was increased by ~۷°C after NIR irradiation, whereas the tumors in magnetic targeting group showed a temperature rise of ~۱۲°C. Conclusion: The in vivo antitumor assessment revealed that intraperitoneal injection of Fe۲O۳@Au nanoparticles and their targeting via magnetic field toward the tumor followed by NIR irradiation remarkably inhibited tumor growth and induced extensive necrosis. Therefore, Fe۲O۳@Au can establish a targeted MRI-guided PTT strategy.

کلیدواژه ها:

Photothermal Therapy ، Hyperthermia ، iron-gold nanoparticle ، Colon cancer