Comparison of forward intensity modulated radiation therapy and two field tangential wedged beam techniques in radiotherapy of breast cancer: dosimetric and radiobiologic study

Introduction: This study aims to compare the dose delivery parameters and radiobiologic model prediction of Tumor Control Probability (TCP) of the FIMRT technique compared with rectangular two tangential wedged fields (۲FW) in the treatment of breast cancer. Furthermore, reduction of the heart and lung dose in the FIMRT was studied via dosimetric parameters and radiobiologic model prediction of Normal Tissue Complication Probability (NTCP). Materials and Methods: ۲۵ left-sided breast cancer patients were selected. The planning target volume (PTV) and organs at risk (heart ad ipsilateral lung) were countered. The tangential technique of treatment planning consists of two optimized wedged beam (۲FW) were compared to FIMRT plans for same patients. The FIMRT and ۲FW was planned for delivery of ۵۰Gy dose to the target for ۲۵ fractions. The minimum dose, maximum dose, mean dose and homogeneity index (HI) of the dose for the PTV were obtained for both techniques.  Moreover, maximum and mean dose for the lung and heart tissues were obtained. The monitor unit (MUs) and the PTV۹۷% were recorded. Paired samples t-test was used for statistical analysis and p<۰.۰۵ was considered as significant level. TCP and NTCP for radiation pneumonitis and late heart mortality was calculated with the Lyman model for organs at risk using dose-volume histogram (DVH). Results: the homogeneity index between the two techniques was significant (p>۰.۰۵), HI= ۱.۳۲ vs ۱.۱۰ for ۲FW and FIF, respectively. Mean dose to the breast PTV as mean±standard deviation value was ۴۶.۶±۰.۵ Gy for FIMRT vs. ۴۶.۸±۱.۳ Gy for ۲FW plans. The PTV۹۷% was ۹۲.۵%± ۳.۲%, and ۹۱.۱%± ۳.۷ for the FIMRT and ۲FW. The MUs of the ۲FW plans and FIMRT plans were ۳۲۶.۴±۱۱.۲ and ۲۱۲±۱۰.۳, respectively. With the FIMRT, the mean dose of the heart and the lung was (۲.۹Gy vs. ۱.۹Gy) and (۱۲.۱Gy vs. ۸.۳Gy) respectively; the maximum doses in the heart and lung were decreased significantly from (۳.۵Gy to ۲.۱Gy) and (۱۵.۸Gy to ۱۰.۲Gy) in favor of the FIMRT plans. TCP was ۷۲.۳% for FIMRT and ۷۲.۱% for ۲FW plans. The NTCP for radiation pneumonitis was (۰.۴%±۰.۱%) and (۰.۶%±۰.۵%) for the FIMRT and ۲FW techniques, respectively. The NTCP for late heart was (۶.۱%±۲.۱%) for the ۲FW technique. However, it was reduced to (۳.۸%±۱.۹%) in the FIMRT technique. Differences of the NTCP values were statistically significant for both lung and heart (p<۰.۰۵). Conclusion: the treatment MUs were significantly reduced by the FIF-RT technique (p<۰.۰۵). For all organs, mean NTCP were lower for FIMRT than for the ۲FW plans. The FIMRT delivered more homogenous dose to the target while maintaining or increasing the TCP. The FIMRT technique can be considered as a straightforward and fast technique to use clinically particularly in clinics that have not inverse IMRT.

کلیدواژه ها:

Radiobiologic modeling FIMRT ، Breast cancer Conformal Radiotherapy Dosimetry ، Heart dose Lung dose