The global survival rate of graft and patient in kidney transplantation of children: a systematic review and meta-analysis

Background and Objectives: This study is a systematic review and meta-analysis on published studies about the Global Survival Rate of Graft and Patients in the Kidney Transplantation of children.Materials & Methodss: Studies that investigated the survival rate of kidney transplants published until the ۳۰th of December ۲۰۲۰ were selected using a systematic search strategy in the following databases: Medline, Embase, Scopus, ProQuest, ISI Web of Science, and Cochrane. The extracted data were entered into the Excel software and STATA ۱۶.۰. The search identified ۶۰۰۷ study references. From the total, we excluded ۱۳۴۸ duplicates, ۳۶۸۸ reference titles and abstracts that were deemed irrelevant, and ۸۴۶ references that were not original articles (i.e., letter, commentary, review) or did not meet the inclusion criteria. As such, ۸۹ studies involving ۱۲, ۳۳۰ participants were included in this meta-analysis.Finding: In this study ۱, ۳, ۵, ۷ and ۱۰-year survival rates of graft were estimated to be ۹۲, ۸۳, ۷۴.۴۰, ۶۷.۱۰, and ۶۳.۵۰%, respectively. Also, ۱, ۳, ۵, ۷ and ۱۰-year survival rates of patients were estimated to be ۹۹.۶۰, ۹۷.۳۰, ۹۵.۲۰, ۷۴.۶۰, and ۹۷.۹۰%, respectively. In all, one-, three-, five-, seven-, and ۱۰-year graft survival is higher in Asia than on any other continent. North America has the lowest graft survival, except for ۱-year of graft survival, whereas South America reports lower.Conclusionss: The findings suggest differences in graft and patient survival among children with kidney transplants. Although differences in ethnic origin, incompatibility with deceased donor kidneys, and types of kidney disease are unavoidable, interventions to improve preventive and living-donor transplantation are particularly needed in minority groups. In addition, more research is needed to establish and address the contribution of medical and sociocultural barriers to preferential treatment of these groups.

کلیدواژه ها:

Kidney transplantation ، Survival analysis ، Meta-analysis