Investigation of the Potential of Niosomes to Load Different Drugs

Background and Objectives: The use of nanotechnology in new drug delivery systems is expanding day to day because currently more than ۹۰% of new substances that have therapeutic properties have weak biopharmaceutical characteristics, therefore, systems. Appropriate drug delivery should be developed to distribute active pharmaceutical molecules without side effects on healthy organs and tissues, precisely in the required place. In the field of pharmaceuticals, drug delivery systems using vesicular carriers have attracted much attention in recent years, because these carriers can provide high efficiency in encapsulation, controlled release, and flexibility in structure. provides hydrophilic and hydrophobic transport, biocompatibility, biodegradation, long-term blood circulation, and targeting to a specific area. In general, targeted active and non-active drug delivery of nanocarriers has been studied for the treatment of many diseases. The purpose of this study is to investigate the potential of niosome nanocarriers and introduce optimal niosome formulation for various types of anticancer, anti-skin, peptide, ocular, etc. drugs.Materials & Methods: A summary of the obtained information and results was collected by reviewing review articles in reputable journals, printed books, and checking various databases.Findings: There are several factors such as the type and concentration of non-ionic surfactant, the method of preparing niosomes, the hydration temperature, the presence or absence of an induction charge, etc., which affect the formation of niosomes, efficiency, size distribution, and particle stability. Also, encapsulating the drug in the vesicular system prolongs its presence in systemic circulation. It increases the possibility of penetration into the target tissue, and in the case of achieving selective absorption, selective absorption reduces drug toxicity.Conclusions: Niosomes, which are nanovesicles composed of non-ionic surfactants, are considered for targeted delivery due to their stability in storage and economic efficiency. These characteristics have turned niosomes into suitable nanocarriers in treating diseases of various origins. Therefore, it seems that the field of research is ready for the production of suitable niosomes and it can lead to providing suitable formulations in the pharmaceutical industry.

کلیدواژه ها:

nanotechnology ، drug delivery ، nanocarrier ، niosome ، non-ionic surfactant