Preeclampsia: Ranking the genes and associated biological functions

Background and aims: Preeclampsia is a gestation-specific disorder and it is one of the most important causes of fetal and maternal morbidity and mortality in the whole world. The purpose of this research was to compile all the genes related to Preeclampsia and determine the top ten genes as well as determine the most important biological functions related to this disease. Methods:A comprehensive review was performed using the PubMed database and data were taken from research articles published between ۱۹۹۵ and January ۲۰۲۲. To evaluate the association between di↵erent genes and preeclampsia, we selected the articles with significant association (p-value < ۰.۰۵) with preeclampsia. The GeneMANIA Cytoscape and Cytoscape’s plugin CytoHubba apps were used to investigate these associations, visualize the gene network and discover key nodes (genes) in this biological network.Results:After reviewing the ۷۹۶ articles, ۳۵۶ articles were included in our study. Our results showed that ۲۰۷ genes are associated with the risk of Preeclampsia. Based on Maximal Clique Centrality, the top ten genes that have significant associations with Preeclampsia are AGTR۲, CCR۵, CXCR۲, DRD۴, GNB۳, AGTR۱, CXCR۴, AGT, CXCL۱۲, and CXCL۸. In addition, nitric-oxide synthase biosynthetic process and regulation of nitric-oxide synthase biosynthetic process are the two most important biological functions with a ۴۸.۹۶ enrichment score related to Preeclampsia. Conclusions: This study provides novel insights to the pathomechanism of Preeclampsia. The outcomes of this study revealed the top ten genes that have significant associations with Preeclampsia. Additionally, the biological functions related to Preeclampsia were ranked based on their enrichment scores.

کلیدواژه ها:

association ، bioinformatic ، biological network ، gene network ، preeclapsia