Analysis of TPD۵۲ gene in prostate adenocarcinoma and probability analysis of rs۷۵۷۴۴۳۸۳۱ in hsa-mir-۳۳a-۵p

Prostate cancer is the second most common cancer and the fifth leading cause of cancer-related death in men.The progression of cancer in the prostate is a gland in the male reproductive system.Most prostate cancers grow slowly, but some grow relatively quickly.Cancer cells can spread from the prostate to other parts of the body, especially the bones and lymph nodes.This cancer may not show symptoms at first and in its more advanced stages can cause problems such as blood in the urine or pain in the pelvis and waist when urinating.Factors that increase the risk of prostate cancer are age.High and especially genetic. The TPD۵۲ gene activates calcium ion binding activity and protein homodimerization activity and is involved in B cell di↵erentiation located in the endoplasmic reticulum region and the nuclear-cytoplasmic nuclear region. Materials and MethodThe TPD۵۲ gene,which activates calcium ion binding activity and protein homodimerization activity involved in B cell di↵erentiation, was selected at the NCBI site.The expression of this gene was studied at the GEPIA۲ site.The microRNAs that acted on this gene were then examined at the MIRWALK site. In LNCRNASNP۲, these microRNAs were examined for expression in prostate adenocarcinoma,and finally,the e↵ectiveness of SNPs on microRNAs at the MIRNASNP site was investigated.DiscussionThe TPD۵۲ gene is much more expressed in tumors.The selected has-mir-۳۳a-۵p MIRNA had a score:۱ and np:۱۲ and this MIRNA has a great e↵ect on the TPD۵۲ gene.This MIRNA had an expression of ۱۱.۸۳ in prostate adenocarcinoma and many SNPs affect this MIRNA.ConclusionSNPs are high-density natural sequence variations in genomes and are considered a major genetic source of phenotypic variation within a species and are considered important genetic markers.Based on previous research,it is predicted that SNP rs۷۵۷۴۴۳۸۳۱ is generated between the gene and MIRNA and causes functional dysfunction.

کلیدواژه ها:

LNC ، GENE ، PROSTATE ، MIRNA ، TPD۵۲ ، CANCER