Investigating The Second and Third Structure of Squalene Synthetase Transferase Gene in Dracocephalum kotschyi Plant

SQS is an unsaturated compound containing six double bonds, the richest source of which is shark liver oil, which traditionally has many uses and its main use is medicine. It is very important to predict the secondary and tertiary structure of proteins in subsequent protein studies and to study and identify the e ciency of unknown proteins. Also, prediction of protein tertiary structure can be used in molecular docking. Due to the important role of SQS in the defense system, it is important to investigate the secondary and tertiary structure of this receptor. In this study, the Phyre۲ software was used to investigate the secondary structure of the SQS protein. The results indicate that six similar structures were found in the protein database for SQS, one of these structures, called the crystal structure of a d۱ezfa, had a similarity of ۹۲%. Three-dimensional structure modeling was performed based on the selection of a pattern with a high resemblance to the target protein using the Swiss Model database. Three-dimensional structure modeling was performed based on the selection of a pattern with a high resemblance to the target protein using the Swiss Model database. The model chosen for modeling SQS protein in Homo sapiens (FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE) (۱EZF) contains ۳۴۰ amino acids and discovered by X-RAY DIFFRACTION with a resolution of ۲.۱۵ angstroms. The Identity of ۱EZF pattern with target, protein is ۳۰.۷۸. The results of this research can be used in future research and molecular docking and provide basic information to investigate other immune receptors.

کلیدواژه ها:

۳D structure ، ۲D structure ، Swiss Model Phyre۲ ، Docking