Identification of Candidate Genes Associated with Cisplatin Resistance in Ovarian Cancer

Among women’s malignancies, ovarian epithelial cancer is the fourth cause of women’s death among all types of cancer in the world. Poor prognosis is estimated to be the main reason for the high death rate. Most of the patients with advanced stage ovarian cancer, experience cancer recurrence, most of these tumors are resistant to cisplatin. Cisplatin is a chemotherapy drug, and di↵erences in the DNA damage response provide a useful explanation for its early sensitivity in ovarian cancer. While the body’s normal cells mostly can deal with the damage of restricted dosage of the drug, tumor cells that lack proper DNA repair system cannot and die. However, cancer cells go through several processes to become drug resistant. we analyze the di↵erently expressed genes in RNAseq PRJNA۳۸۴۳۵۲ (A۲۷۸۰S vs A۲۷۸۰CP) and PRJNA۷۳۵۳۹۷ (chemotherapyresistant vs. chemotherapy-sensitive A۲۷۸۰ cell lines) and PRJNA۷۲۴۶۸۰ (A۲۷۸۰S vs A۲۷۸۰CP) and PRJNA۵۹۴۲۱۱ (ovarian cancer cisplatin resistance vs sensitive tissues). By intersecting the differently expressed genes, ۳۱۴ genes were identified. Then, further function enrichment analysis, including GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis, was performed. In this study we aimed to identify possible related pathways and genes in platinum based ovarian cancer drug resistance. Finally, we find out that TMEMs (Transmembrane protein family members) may play a vital role in chemoresistance.

کلیدواژه ها:

ovarian cancer ، chemoresistance ، pathway analysis