Candidate prognostic gene signatures in lung cancer risk amongasthmatic and COPD patients

The second most frequent cancer in the world is lung cancer (LC). It is clear that both inherited and environmentalfactors contribute to the onset and progression of various respiratory diseases. According to reports, some disorders,including asthma and chronic obstructive pulmonary disease (COPD), elevate the risk of LC. Therefore, this studyaims to find common genes and biological pathways in patients with LC/COPD and LC/asthma so that perhapswe can achieve a better understanding of the progression of LC from other pulmonary disorders. In the currentstudy, the nine microarray datasets (three for asthma, four for LC, and two for COPD) were selected from theNCBI GEO database to explore differentially and commonly expressed genes as well as unique and shared biologicalpathways involved in LC/asthma and LC/COPD patients. Nine datasets, including ۵۴۷ individuals, were includedin the analysis. Our results showed that ۴۶ and ۲۳ candidate signatures predicted the incidence risk of LC fromasthma and COPD, respectively. Furthermore, common biological pathways involved in LC/asthma and LC/COPDpatients were ۲۸ and ۲۲, respectively. It may be possible to predict the incidence risk of LC from asthma andCOPD by looking at the specific and shared essential genes and biological pathways involved in LC/COPD andLC/asthma. The importance of the key genes for COPD and asthma in predicting LC should be investigated further

کلیدواژه ها:

Lung cancer ، asthma ، COPD ، prognostic genes ، Microarray