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Voluntary exercise improves pulmonary inflammation through NF-κB and Nrf-2 in type 2 diabetic male rats

سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 169

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شناسه ملی سند علمی:

JR_IJBMS-27-1_010

تاریخ نمایه سازی: 18 آذر 1402

چکیده مقاله Voluntary exercise improves pulmonary inflammation through NF-κB and Nrf-2 in type 2 diabetic male rats

Objective(s): This study aimed to evaluate the effects of voluntary exercise as an anti-inflammatory intervention on the pulmonary levels of inflammatory cytokines in type 2 diabetic male rats.Materials and Methods: Twenty-eight male Wistar rats were divided into four groups (n=7), including control (Col), diabetic (Dia), voluntary exercise (Exe), and diabetic with voluntary exercise (Dia+Exe). Diabetes was induced by a high-fat diet (4 weeks) and intraperitoneal injection of streptozotocin (35 mg/kg), and animals did training on the running wheel for 10 weeks as voluntary exercise. Finally, the rats were euthanized and the lung tissues were sampled for the evaluation of the levels of pulmonary interleukin (IL)-10, IL-11, and TNF-α using ELISA, and the protein levels of Nrf-2 and NF-κB using western blotting and tissue histopathological analysis. Results: Diabetes reduced the IL-10, IL-11, and Nrf2 levels (P<0.001 to P<0.01) and increased the levels of TNF-α and NF-κB compared to the Col group (P<0.001). Lung tissue levels of IL-10, IL-11, and Nrf2 in the Dia+Exe group enhanced compared to the Dia group (P<0.001 to P<0.05), however; the TNF-α and NF-κB levels decreased (P<0.001). The level of pulmonary Nrf2 in the Dia+Exe group was lower than that of the Exe group while the NF-κB level increased (P<0.001). Moreover, diabetes caused histopathological changes in lung tissue which improved with exercise in the Dia+Exe group. Conclusion: These findings showed that voluntary exercise could improve diabetes-induced pulmonary complications by ameliorating inflammatory conditions.

کلیدواژه های Voluntary exercise improves pulmonary inflammation through NF-κB and Nrf-2 in type 2 diabetic male rats:

نویسندگان مقاله Voluntary exercise improves pulmonary inflammation through NF-κB and Nrf-2 in type 2 diabetic male rats

Seyed Zanyar Athari

Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

Fariba Mirzaie Bavil

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Rana Keyhanmanesh

Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Hajie Lotfi

Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran

Yousef Sajed

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Aref Delkhosh

Department of Pathobiology, Faculty of Veterinary Medicine, Division of Pathology, Urmia University, Urmia, Iran

Fariba Ghiasi

Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

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