Chemical composition of essential oils of Citrus limon peel from three Moroccan regions and their antioxidant, anti-inflammatory, antidiabetic and dermatoprotective properties
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 97
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شناسه ملی سند علمی:
JR_HERM-12-1_011
تاریخ نمایه سازی: 14 آذر 1402
چکیده مقاله:
Introduction: The current study aimed to explore the in vitro antioxidant, anti-inflammatory, antidiabetic, and dermatoprotective properties of lemon peel essential oil (EO).
Methods: The chemical composition of lemon EOs extracted from the lemon of three cities in Morocco was investigated using gas chromatography-mass spectrometry (GC-MS) analysis. The antioxidant property was estimated by two complementary tests: Ferric ion reducing antioxidant power (FRAP) and ۱,۱-diphenyl-۲-picrylhydrazyl (DPPH). The in vitro anti-inflammatory activity was assessed by the inhibition of albumin denaturation and proteinase. Inhibitory properties of α-glucosidase and α-amylase were used to reveal the antidiabetic activity of lemon peel EOs. Dermatoprotective property was evaluated by the tyrosinase inhibition method.
Results: In addition to high amounts of polyphenols and flavonoids, GC-MS analysis of lemon peel EOs demonstrated the presence of D-limonene, β–pinene, and γ-terpinene as the main compounds in the three samples studied. Lemon peel EOs exhibited significant antioxidant activities by IC۵۰ values ranging from ۴۰.۵۷ μg/mL to ۱۰۰.۲۲ μg/mL and ۱۱۳.۶۳ μg/mL to ۱۸۰.۹۰ μg/mL obtained by DPPH and FRAP tests, respectively. in vitro inhibition of enzymes involved in inflammatory response revealed that lemon peel EOs presented remarkable inhibitory activities against albumin denaturation (۲۳۰.۴۸ μg/mL > IC۵۰ < ۳۴۱.۱۳ μg/mL) and proteinase (۱۹۹.۷۰ μg/mL > IC۵۰ < ۳۰۷.۰۵ μg/mL). Moreover, lemon peel EOs demonstrated powerful inhibition of α-amylase and α-glucosidase with various IC۵۰ values (۱۶۸۹.۰۶ μg/mL > IC۵۰ > ۴۰۰۰ μg/mL and ۱۰۲۱.۵۸ μg/mL > C۵۰ < ۲۴۶۷.۶۲ μg/mL), respectively. These EOs also revealed significant inhibition of tyrosinase with IC۵۰ values ranging from ۲۴۸.۴۲ μg/mL to ۳۷۸.۰۲ μg/mL.
Conclusion: These results revealed that lemon peel EOs might constitute a new product with beneficial biological abilities against the mentioned complications.
کلیدواژه ها:
نویسندگان
Merian El Aboudi
Laboratory of Natural Resources and Sustainable Development, Biology department, Ibn Tofail University, Faculty of Sciences, Kenitra, Morocco
Douae Ben Hdech
UPRI Plant Science, Interactions and innovation, Campus Jean-Henri Fabre, Pole Agroscience, Avignon
Samir Bikri
Laboratory of biology and health, Biology department, Ibn Tofail University, Faculty of Sciences, Kenitra, Morocco
Asmae Benayad
Laboratory of biology and health, Biology department, Ibn Tofail University, Faculty of Sciences, Kenitra, Morocco