The Effect of Aerobic Training and Coriandrum sativum Extract on Some Oxidative Stress Factors in Male Diabetic Wistar Rats

Background & Objectives: Currently, diabetes is a major problem. Increased level of blood sugar is one of the effective factors in oxidative stress. Former studies showed that sports and herbal medicines are the non-pharmaceutical treatments for diabetes. Accordingly, we aimed to evaluate the effect of aerobic training and Coriandrum sativum extract on some oxidative stress factors in male diabetic rats. Materials & Methods: The present study was conducted on ۴۰ male Wistar rats randomly divided into control, training, extract-training, and extract groups. Diabetes was induced through intraperitoneal injection of streptozotocin (۵۵ mg/kg of body weight). After induction of diabetes, the training group performed aerobic training for six weeks (۵۰-۵۵% maximum oxygen uptake). The extract group was orally administered Coriandrum sativum extract (۱۵۰ mg/kg of body weight daily). After six weeks, serum levels of total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) were measured. Results: The results showed aerobic training and consumption of Coriandrum sativum extract significantly increased serum levels of TAC, SOD, and CAT and significantly lowered serum level of MDA (P<۰.۰۵). Conclusion: It can be concluded that aerobic training along with Coriandrum sativum extract can improve antioxidant defense system and diminish oxidative factors in diabetic patients.

کلیدواژه ها:

Aerobic training ، Diabetes ، Coriandrum sativum extract ، Oxidative stress ، استرس اکسیداتیو ، تمرین هوازی ، دیابت ، عصاره دانه گشنیز