Comparison of aglycon and glycosidic saponin extracts of Cyclamen coum tuber against Candida spp.

سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 168

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شناسه ملی سند علمی:

JR_CUMM-2-2_007

تاریخ نمایه سازی: 11 آذر 1402

چکیده مقاله:

Background and Purpose: Candidiasis, an important fungal infection, is considered the fourth most common nosocomial blood stream infection. Nowadays, because of increased fungal resistance to antibiotics, the use of herbal medicine has gained particular attention. Cyclamen species are medicinal plants containing triterpenoid saponins, which are shown to have antimicrobial properties. Materials and Methods: Three species of Candida including C. albicans ۱۰۲۳۱, C. tropicalis ۰۷۵۰, and C. krusei and nine clinical samples were cultured on Sabouraud dextrose agar. Active substances of the tubers were extracted by fractionation method. Susceptibility of Candida to Cyclamen coum tuber extracts was evaluated via minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC). Results: Our results demonstrated that ethyl acetate extract had no inhibitory effect on Candida strains, whereas the aqueous and n-butanolic extracts showed considerable activity. MIC and MFC of these extracts varied within the range of ۲-۳۲ μg/mL of saponin for different Candida samples. Aglyconic aqueous phase of the extract had the most effective anticandida activity. Glycosidic and aglyconic aqueous extracts were less active on C. albicans strains and C. tropicalis, respectively. Conclusion: Tuber extract of Cyclamen was rich in triterpenoid saponins and had antifungal effect. Sugar chain structure, as well as type and concentration of the aglycones were effective in this activity.

نویسندگان

Seyedeh Toktam Sajjadi

Department of Plant Sciences, Faculty of Biological Sciences, Alzahra University, Tehran, Iran

Azra Saboora

Department of Plant Sciences, Faculty of Biological Sciences, Alzahra University, Tehran, Iran

Parisa Mohammadi

Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran

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  • Saad A, Fadli M, Bouaziz M, Benharref A, Mezrioui NE, ...
  • Sortino M, Cechinel Filho V, Correˆab R, Zacchino S. N-Phenyl ...
  • Bertout S, Dunyach C, Drakulovski P, Reynes J, Mallie M. ...
  • Shreaz S, Bhatia R, Khan N, Muralidhar S, Seemi FB, ...
  • Stuardo M, San Mart´ın R. Antifungal properties of quinoa (Chenopodium ...
  • Marzouk B, Marzouk Z, Décor R, Edziri H, Haloui E, ...
  • Mert-Türk F. Saponins versus plant fungal pathogens. J Cell Mol ...
  • Hassan SM, Haq AU, Byrd JA, Berhow MA, Cartwright AL, ...
  • Lanzotti V, Romano A, Lanzuise S, Bonanomi G, Scala F. ...
  • Calis I, Yuruker A, Tanker N, Wright AD, Sticher O. ...
  • Altunkeyik H, Gülcemal D, Masullo M, Alankus- Caliskana O, Piacenteb ...
  • Ma L, Gu YC, Lou JG, Wang JS, Huang XF, ...
  • Turkoglu A, Duru ME, Mercan N, Kivrak I, Gezer K. ...
  • Damke E, Tsuzuki JK, Cortez DA, Ferreira IC, Bertoni TA, ...
  • Wu J, Lin L, Chau FT. Ultrasound-assisted extraction of ginseng ...
  • Marrinova D, Ribarov F, Atanassova M. Total phenolics and total ...
  • IBM Corp, Released. IBM SPSS statistics for windows. Armonk, NY: ...
  • Gyawali R, Ibrahim SA. Natural products as antimicrobial agents. Food ...
  • Deeptanshu S. Saponin and its biological actions with special reference ...
  • Sparg SG, Light ME, van Staden J. Biological activities and ...
  • Pawar HA, Shenoy AV, Narawade PD, Soni PY, Shanbhag PP, ...
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