Oropharyngeal candidiasis in HIV/AIDS patients and non-HIV subjects in the Southeast of Iran
محل انتشار: مجله قارچ شناسی پزشکی، دوره: 4، شماره: 4
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 102
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شناسه ملی سند علمی:
JR_CUMM-4-4_001
تاریخ نمایه سازی: 11 آذر 1402
چکیده مقاله:
Background and Purpose: Candida species are the common opportunistic pathogens during the course of human immunodeficiency virus (HIV) infection. Oropharyngeal candidiasis (OPC) is generally known as the initial sign of HIV infection. The aim of this study was to compare demographic characteristics and frequency of Candida species between HIV/AIDS patients and non-HIV subjects in Kerman, southeast of Iran. Materials and Methods: This study was conducted on ۱۴۳ samples collected from the oral cavity of ۸۱ HIV/AIDS patients and ۳۵ non-HIV subjects. The samples were cultured on Sabouraud dextrose agar and CHROMagar. The identification of Candida species was accomplished using the color of colony and polymerase chain reaction-restriction fragment length polymorphism. Results: According to the results, C. albicans (n=۲۵, ۶۹.۱۴%) was the most prevalent species isolated from the HIV/AIDS patients, followed by C. glabrata (n=۱۹, ۲۳.۴۶%). Other isolated species included C. parapsilosis (n=۴, ۴.۹۴ %), C. krusei (n=۱, ۱.۲۴%), and C. kefyr (n=۱, ۱.۲۴%). Out of the ۳۵ Candida species recovered from the oral samples of non-HIV subjects, ۲۳ (۶۵.۷۱%) and ۱۲ (۳۴.۲۹%) cases were C. krusei and C. albicans, respectively. Candida krusei was the only non-albicans species found in the non-HIV subjects that was also the predominant isolated species. Regarding the HIV/AIDS patients, the highest prevalence of OPC was observed in the age group of ۴۱-۵۰ years. However, in the non-HIV subjects, the age group of ۳۱-۴۰ years had the highest prevalence of this infection. Furthermore, no correlation was observed between the gender and number of Candida isolates. Conclusion: Consideration of the epidemiologic data showed that the two groups were significantly different in terms of the prevalence of Candida species, which could play a major role in the selection of effective drugs for the treatment of candidiasis.
کلیدواژه ها:
نویسندگان
Samira Salari
Department of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran
Pooya Ghasemi Nejad Almani
Department of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran
Abbas Hosain pour
Department of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran