A multi-centered study of Pneumocystis jirovecii colonization in patients with respiratory disorders: Is there a colonization trend in the elderly?

سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 83

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شناسه ملی سند علمی:

JR_CUMM-5-3_004

تاریخ نمایه سازی: 11 آذر 1402

چکیده مقاله:

Background and Purpose: Pneumocystis jirovecii colonization plays a key role in the progression of pulmonary infection. However, there are limited data regarding the colonization of these fungi in the patients residing in different regions of Iran. Regarding this, the present study was conducted to evaluate the prevalence of P. jirovecii colonization in non-HIV-infected patients with respiratory failure introduced by physicians using nested polymerase chain reaction (PCR). Materials and Methods: This study was conducted on ۱۳۶ samples obtained from ۱۳۶ patients with respiratory disorders referring to different hospitals in the capital and north of Iran during ۲۰۱۳-۲۰۱۵. The samples were collected using bronchoalveolar lavage (BAL; n=۱۲۱) and sputum induction (n=۱۵). Nested PCR method targeting mtLSU rRNA gene was used for the detection of P. jirovecii DNA in the specimens. Results: The nested PCR analysis resulted in the detection of P. jirovecii DNA in ۳۲ (۲۳.۵%) patients. The mean age of the participants was ۴۹.۰۴±۱۱.۹۴ years (age range: ۱۴-۹۰ years). The results revealed no correlation between Pneumocystis colonization and gender. The studied patients were divided into two groups of immunocompromised and immunocompetent patients. In the regard, ۲۵.۴% of the patients with detectable P. jirovecii DNA were immunocompromised and had cancer, organ transplantation, asthma, sarcoidosis, dermatomyositis, chronic obstructive pulmonary disease, bronchiectasis, and pulmonary vasculitis. On the other hand, Pneumocystis DNA was detected in ۲۱.۸% of the immunocompetent patients. Frequencies of P. jirovecii DNA detection in the patients with tuberculosis, hydatid cyst, and unknown underlying diseases were obtained as ۲۰.۸%, ۲۵%, and ۲۲%, respectively. The prevalence of Pneumocystis colonization varied based on age. In this regard, P. jirovecii colonization was more prevalent in patients aged above ۷۰ years. Conclusion: As the findings indicated, non-HIV-infected patients, especially the elderly, had a high prevalence of P. jirovecii colonization. Therefore, these patients are probably a potential source of infection for others. Regarding this, it is of paramount importance to adopt monitoring and prophylactic measures to reduce this infection.

نویسندگان

Mahdi Abastabar

Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran

Elham Mosayebi

Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Tahereh Shokohi

Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Mohammad Taghi Hedayati

Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Mohammad Reza Jabari Amiri

Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Zahra Seifi

Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Iman Haghani

Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Masoud Aliyali

Department of Internal Medicine, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Sasan Saber

Department of Internal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Maryam-Fatemeh Sheikholeslami

Department of Molecular Pathology, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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