Candidemia: Changing dynamics from a tertiary care hospital in North India
محل انتشار: سرطان معده، دوره: 8، شماره: 1
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 50
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شناسه ملی سند علمی:
JR_CUMM-8-1_004
تاریخ نمایه سازی: 11 آذر 1402
چکیده مقاله:
Background and Purpose: Routine identification of Candida species and knowledge of antibiotic susceptibility patterns can prevent diagnostic delays and help clinicians choose appropriate empirical therapies. This study aimed to identify and speciate Candida isolates from bloodstream infections and evaluate their epidemiological profile and antibiotic susceptibility pattern in a tertiary care hospital in North India.Materials and Methods: Blood samples were cultured in the Department of Microbiology of a tertiary care hospital from January ۲۰۱۹ to May ۲۰۲۱, and the samples which showed growth of Candida species (spp.) were included in this study.Candida isolates were initially characterized by conventional techniques. Further identification and antifungal susceptibility testing were performed using Vitek ۲ compact automated system. Data analysis was performed using the SPSS software (Version ۲۵.۰).Results: Candida spp. were isolated from a total of ۱۱۶ blood samples, ۶۰.۹۲% of which belonged to males. The majority (۴۳.۱۰%) of isolates were obtained from ۰-۱-month-old neonates, followed by infants (۱۶.۳۸%) and children in the age range of ۱-۱۷ years (۱۶.۳۸%). Only ۶.۸۹% of isolates were obtained from adults older than ۱۸ years. Candida tropicalis (۲۶.۷۲%) was the most common species, followed by Candida pelliculosa (۱۹.۸۳%), Candida albicans (۱۷.۲۴%), Candida parapsilosis (۱۴.۶۶%), Candida famata (۹.۴۸%), and Candida krusei (۹.۴۸%). Other isolated species included Candida lusitaniae, Candida sphaerica, and Candida inconspicua. Out of ۱۱۶ isolates,۱۰۱ isolates were subjected to Vitek ۲ susceptibility testing. Overall, ۲۱.۷۸% (۲۲/۱۰۱) of Candida isolates were found to be resistant/intermediate. Among C. albicans isolates,resistance was observed only against voriconazole (۲۰%) and fluconazole (۵%); however, among non- albicans Candida species (NAC), resistance was observed against flucytosine (۱۶.۰۴%), followed by fluconazole (۱۴.۸۱%), voriconazole (۳.۷۰%), and caspofungin (۳.۷۰%).Conclusion: Non-albicans Candida spp. predominated over Candida albicans in causing bloodstream infections and were found to be more resistant to antifungals.Continuous surveillance is necessary to monitor changes in epidemiological and resistance patterns.
کلیدواژه ها:
نویسندگان
Garima Gautam
Department of Microbiology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India
Deepti Rawat
Department of Microbiology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India
Ravinder Kaur
Department of Microbiology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India
Masoom Nathani
Department of Microbiology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India
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