Phototherapy Effects on Zinc Level of Neonates With Hyperbilirubinemia: A Systematic Review and Meta-analysis

سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 77

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شناسه ملی سند علمی:

JR_JPRE-11-2_002

تاریخ نمایه سازی: 9 آذر 1402

چکیده مقاله:

Background: Phototherapy is the most common treatment of neonatal jaundice that affects the zinc level as well as the bilirubin level. Objectives: The purpose of this study is to investigate the effect of phototherapy on the zinc level of infants with jaundice by a systematic review and meta-analysis. Methods: In this systematic review and meta-analysis a comprehensive literature search of the databases, including Cochrane Library, Web of Science, PubMed, Scopus, and Google Scholar web browser was conducted using standard keywords. Data analysis of this meta-analysis was performed using STATA software, version ۱۴ and P<۰.۰۵ was considered a significant level for tests.  Results: In the five studies reviewed in this article with a sample size of ۳۹۸ individuals, phototherapy increased the level of zinc [Standardized mean difference (SMD): ۰.۸۸ (۹۵% CI: ۰.۳۸, ۱.۳۸), P<۰.۰۰۱] and decreased bilirubin level [SMD: -۷.۶۷ (۹۵% CI: -۹.۱۱, -۶.۲۳), P<۰.۰۰۱] in infants with jaundice. The effect of phototherapy was on the zinc level of these groups: infants with a birth weight of ۳۰۰۰ to ۳۳۰۰ grams (gr) [SMD: ۱.۰۷ (۹۵% CI: ۰.۴۲, ۱.۷۱), P<۰.۰۰۱] and ۳۳۰۱ to ۳۶۰۰ gr [SMD: ۰.۴۰ (۹۵% CI: -۰.۳۲, ۱.۱۲), P=۰.۰۲۸], three-day-old infants [SMD: ۱.۰۵ (۹۵% CI: ۰.۳۵, ۱.۷۴), P<۰.۰۰۱], four-day-old [SMD: ۰.۷۶ (۹۵% CI: ۰.۲۶, ۱.۳۲)], and ۵-day-old ones [SMD: ۰.۲۳ (۹۵% CI: -۰.۰۱, ۰.۴۸)]. In addition, phototherapy affected on zinc level of those whose gestational age (GA) was ۳۷ [SMD: ۱.۱۲ (۹۵% CI: ۰.۰۶, ۲.۱۷), P<۰.۰۰۱] and ۳۸ [SMD: ۰.۶۱ (۹۵% CI: ۰.۱۵, ۱.۰۶), P=۰.۰۰۱] weeks. Conclusions: Phototherapy by reducing the level of bilirubin increases the level of zinc in infants with jaundice. So, the standardized mean difference of “phototherapy effects on the zinc level of infants with jaundice” decreases with increasing infants’ weight, increasing infants’ age, and increasing gestational age.

نویسندگان

Diana Sarokhani

Research Center for Environmental Determinants of Health, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Amir Adibi

Department of Child and Adolescent Psychiatry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

Mohsen Abdan

Research Center for Environmental Determinants of Health, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Moloud Fakhri

Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.

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