Microwave-assisted multicomponent reaction for the synthesis of ۲, ۴, ۵-triarylimidazole derivatives using zinc-nickel ferrite magnetic nanoparticlesas a catalyst

Imidazole derivatives have attracted significant attention in recent years due to their diversetherapeutic activities, including antibacterial, antifungal, antiviral, anti-inflammatory,antitubercular, antidepressant, and antitumor effects. Triarylimidazole compounds have gainednotable significance owing to their broad range of biological activities and their utility in syntheticchemistry. The imidazole ring system is a crucial substructure that is commonly found in numerousnatural products and pharmacologically active compounds. Examples of such compounds includethe antiulcerative agent cimetidine, the proton pump inhibitor omeprazole, and the benzodiazepineantagonist flumazenil, all of which are derivatives of imidazole [۱,۲]. In this study, the synthesisof Zn۰.۵Ni۰.۵Fe۲O۴ magnetic nanoparticles by the sol-gel method was carried out. The resultingsample was characterized by FTIR, XRD, TEM, FESEM, EDX, and VSM. The catalytic activityof Zn۰.۵Ni۰.۵Fe۲O۴ MNPs was assessed for the synthesis of ۲, ۴, ۵-triarylimidazole derivativesthrough a three-component reaction under microwave irradiation and solvent-free conditions. Theobtained product was analyzed using ۱H NMR and ۱۳C NMR spectroscopy. This study offersseveral advantageous features, including the environmentally friendly and cost-effective synthesisof nanoparticles, utilization of microwave irradiation under solvent-free conditions, short reactiontimes, simple work-up procedures, and mild reaction conditions..

کلیدواژه ها:

۲ ، ۴ ، ۵-triarylimidazole derivatives ، Microwave irradiation ، Multi-component reacion