Synthesis and characterization of Ni complex supported on MCM-۴۱ as anefficient and reusable nanocatalyst the synthesis of Polyhydroquinolinederivatives

Polyhydroquinolines are important building blocks in the synthesis of many natural productswith a wide range of pharmacological and biological activities including antifertility,anticonvulsant, antibacterial, anticancer, antifungal, antitumor, and also as a mono amine oxidaseinhibitor [۱-۴]. An efficient heterogeneous catalyst has been synthesized by immobilization ofnickel-vanillin complex on MCM-۴۱ nanostructure and characterized by XRD, TGA, BET, EDS,SEM, ICP-OES and FT-IR spectroscopy. The catalytic activity and stability of the preparedcompound has been studied for the synthesis of Polyhydroquinoline derivatives. The simple workup, mild conditions, excellent yield, inexpensive and non-toxic catalyst; render this protocol bothattractive and economically viable. More importance, this catalyst can be reused for several timeswithout any significant loss of its catalytic activity. The synthesis of Polyhydroquinolines is shownin Scheme ۱. The desirable product were synthesised in goog to exellent yeilds

کلیدواژه ها:

Polyhydroquinolines ، MCM-۴۱ ، Ni complex ، Recoverable Catalyst