SiO۲ nanoparticles catalyzed the synthesis oftetrahydro-۲,۶-dioxopyrimidin-۴-yl)-۲,۳-dihydrophthalazine-۱,۴-diones

Multi-component reactions (MCRs) have been considered as asuperior synthetic approachfor the preparation of libraries of biologically active compounds [۱]. MCRs offerenvironmentally friendly methods by reducing the number of waste production, steps of thereactions, and energy consumption [۱].Silica gel is one of the most widely used solid support for various catalytic applications, dueto its non-toxicity, high surface area, excellent thermal stability, and ready availability [۲]. Basedon silica as an efficient catalyst and support, numerous silica-supported catalysts have beendeveloped in recent years [۳]. Also, these catalysts catalyzed the various Multicomponentreactions [۳].In this work, silica nanoparticles (SiO۲-NPs)were applied for the one-pot synthesisof tetrahydro-۲,۶-dioxopyrimidin-۴-yl)-۲,۳-dihydrophthalazine-۱,۴-diones scaffolds. Thesecompounds were prepared via the three-component reaction ofaromatic aldehydes,phthalhydrazide, and barbituric acid (Scheme ۱). After completion of the reaction, the simpleandrapid separation and facial recovery of the SiO۲-NPs was accomplished.

کلیدواژه ها:

Nanoparticles ، SiO۲ ، Solvent-free ، Barbituric acid ، Synthetic methodology