Synthesis, Characterization and Catalysis by Highly ActiveCationicCopper(I) Complexes in the Cycloaddition of Azides and Alkynes

Huisgen ۱,۳-dipolar azide−alkyne cycloaddition is an important reaction in click chemistryand is applied to the preparation of biologically active compounds and biomolecules towardpreclinical and clinical applications.۳ Meldal and coauthors۴ and Sharpless and coauthors۵independently reported the copper-catalyzed azide−alkyne cycloadditions (CuAAC), in which aCu(I) catalyst promotes the reaction regioselectively to afford ۱,۴-substituted ۱,۲,۳-triazols]۱[.Among the most genuine examples of “click chemistry”thecopper-catalyzed Huisgen۱,۳-dipolar cycloaddition of azidesand terminal alkynes (CuAAC)(Scheme ۱) has foundwidechemical applications in many fields,۳,۴rendering ۱,۲,۳-triazolesunder mild and neutralconditions with high efficiency]۲[. After many years of research, it was proven that the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC reaction) could be performed under variousconditions according to the need of click chemistry using the catalysis of various copper saltsthat generate Cu(I) sources in situ [۳,۴].In this work, we have investigated the synthesis,characterization and catalysis by highly active cationic complexes of copper (I) in thecycloaddition of azides and alkynes

کلیدواژه ها:

CuAAC Reaction ، Cycloaddition of Azides and Alkynes ، Click Reaction ، Cu(I)Complex