Synthesis, Characterization and Anticancer Evaluation of NovelMacrocyclic Schiff Base Complexes of Cu(II), Ni(II), and Co(II).

Schiff bases are chemicals that have been functionalized with azomethine or imine and havea wide range of therapeutic uses [۱]. The Schiff base macrocyclic complexes are studied widelybecause of their easy synthesis, versatility and wide range of applications [۲]. Schiff basecomplexes have significantly contributed to the development of modern drug design due to theirsignificance in a number of multi-discipline study fields [۳]. In this work, from the reaction ofnovel polyamine N,N-bis(۲-aminobenzyl)-۲-methoxy aniline with ۲-hydroxy-۵-methylisophthalaldehyde by template method in the presence of metal ions Cu(II), Co(II), andNi(II) with stoichiometric ratios of ۱:۱:۱, mononuclear macrocyclic Schiff base complexescontaining methoxyphenyl moiety as pendant arm were prepared. Proposed structures werepresented based on the methods of elemental analysis, mass spectrometry, FT-IR, anddetermination of molar conductivity. The anticancer activity of these macrocyclic complexes wasalso assessed, using the MTT test, which found that the highest activity was observed for Cu (II)against breast cancer (MCF-۷) cells.

کلیدواژه ها:

Schiff base ، macrocyclic complexes ، anticancer properties