Synthesis of a new potentially octadentate macroacyclic N۸ ligandcontaining two pyridine groups and its corresponding Cu (II) complex andinvestigation of its biological property

In this work, A new potentially octadentate macroacyclic N۸ ligand containing two pyridinegroups (L) was prepared from the direct reaction of a previously known dialdehyde (N’-bis(۵-formylpyrrol-۲-ylmethyl) (A) with ۲-(aminomethyl)pyridine (Fig. ۱). The reaction of this ligandwith Cu(II) metal ion resulted in the formation of a macroacyclic Schiff base complex. Thecompounds were characterized by FT-IR, elemental analysis, ۱H and ۱۳C-NMR. The IR resultsshowed a considerable shift in C=N band of L from ۱۶۳۷ cm-۱ to ۱۶۱۴ cm-۱ upon complexation.Moreover, the splitting of the bands attributed to the ClO۴ counter ion confirmed the complexformation. Also, the antibacterial properties of this compound indicated that the Cu(II) complexhave high antibacterial activity against Bacillus cereus bacteria in a way that its growth inhibitionis much more than that of the reference antibiotics

کلیدواژه ها:

Schiff base complex ، macroacycle ، piperazine ، antibacterial property ، pyridine