Nanomagnetic Cu(II) complex catalyzed synthesis of ۲-amino-۳-cyano-۴Hchromenes

Heterocyclic systems, in particular oxygen-containing structures, constitute a privilegedgroup of compounds based on their wide range of biological activity. Derivatives of ۴Hchromeneshave attracted attention because of containing a pharmacophore group that is found inmany molecules with pharmacological effects, including anticancer, antifungal, antibacterial,antioxidant, and antiprotozoal agents [۱]. ۱,۱۰-Phenanthroline-۵,۶-dione (phendione)-basedtransition-metal complexes are known for their use in pharmacological and catalysis applications[۲,۳]. In this work, a novel Fe۳O۴-supported Cu(II)-complex catalyst was synthesized viafunctionalization of the Fe۳O۴ surface as a support by acetylacetone, followed by treatment withCuCl۲ and phen-dione ligands, and identified by Fourier transform infrared spectroscopy (FTIR),feld emission scanning electron microscopy (FE-SEM), X-ray difraction spectroscopy(EDX), thermogravimetric analysis (TG), and X-ray powder difraction (XRD). The catalyticactivity of the Lewis acid catalyst has been successfully examined in a one-pot, three-componentcondensation reaction of aromatic aldehydes, Lawsone, and malononitrile in ethanol under refluxconditions to furnish ۲-amino-۳-cyano-۴H-chromenes. The proposed approach has someadvantages, such as excellent yields, mild reaction conditions, short reaction times, the use ofagricultural waste, and an eco-friendly nature.

کلیدواژه ها:

Fe۳O۴ ، Copper catalyst ، ۲-amino-۳-cyano-۴H-chromenes ، Levis acid catalyst.