Two Novel Triaza Quinoline Schiff base Ligands and Their MetalComplexes as Antibacterial Compounds: Synthesis, Characterization,structural elucidation and Thermodynamic Studies

In this project, two new tridentate Schiff base ligand and their Zinc(II) and Nickel(II)complexes have been synthesized and characterized using various spectroscopic techniques suchas elemental analysis, magnetic susceptibility, conductivity,۱HNMR, IR, UV-Vis spectra, Massspectrometry powder XRD and EDX. Then their antibacterial effects are described. These newligands behave as tridentate triaza through quinolone moiety nitrogen, azomethine nitrogen, andamine nitrogen. The SQUAD program [۱, ۲] explained the trend of complex formation of metalcomplexes Zn۲+ > Ni۲+ and sequence [ML۱] > [ML۲]. The metal (II) complexes show more potentactivities than their free ligands. The stability constant and Gibbs free energy calculations showthat the tetradentate Schiff base complexes of this series are more stable than the tridentate Schiffbase complexes[۳]. All the synthesized compounds were tested for their antibacterial activity invitro against the Gram-positive bacteria and Gram-negative bacteria indicating that the metalcomplexes are more biologically active than the ligands

کلیدواژه ها:

Quinoline Triaza Schiff Base Complexes ، Thermodynamic Studies ، AntibacterialCompounds