Phosphomolybdic Acid Hydrate Encapsulated in Mil-۵۳ (Fe): A NewHeterogeneous Heteropoly Acid Catalyst for Friedel–Crafts acylation

Phenyl ketones show a significant family of intermediates commonly used in the synthesis ofindustrial chemicals, medicines, cosmetics, and food additives [۱]. Acetylation is one of the mostapplicable, beneficial, and essential reactions in organic chemistry setting chemists to introducereagents for this reaction [۲]. In organic synthesis, this functionality is normally introduced onaromatic rings by acylation with anhydrides or acyl chlorides in the presence of Lewis or protonicacids and solid acids [۳]. Some of the reported methods for the C-acetylation of phenols sufferfrom one or more drawbacks such as toxicity, cost, drastic reaction conditions, hygroscopicity,thermal stability, and the explosiveness of reagents. Given those drawbacks, new, efficient, andeco-friendly methods are still in demand. Herein, A simple, efficient method for the one-potacylation of ۴-fluorophenol via acyl chloride in the presence of a catalytic amount of PMA@ MIL-۵۳(Fe). (Fe) MOF is reported (Figure ۱). This heterogeneous catalyst showed advantages such asbeing very simple and eco-friendly due to the high reusability of the catalyst, excellent yield, andmild reaction conditions.

کلیدواژه ها:

Friedel–Crafts Acylation ، ۴-fluorophenol ، Heterogeneous Catalyst ، PMA@MIL-۵۳(Fe).