Simultaneous inhibitory effect of venetoclaxdrug and anti-Bcl-۲ siRNA loaded by hyaluronateconjugatedPEG- chitosan-lactate nanoparticles for cancerinhibition .
محل انتشار: اولین کنگره بین المللی ژنومیک سرطان
سال انتشار: 1402
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 93
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شناسه ملی سند علمی:
CGC01_308
تاریخ نمایه سازی: 29 آبان 1402
چکیده مقاله:
Introduction: we used the simultaneous inhibition of Bcl-۲,which is an important factor in tumor growth, along with the inhibitionof apoptosis inhibitors Bcl-۲ through venetoclax drug.Materials and Methods: In this study, we used the simultaneousinhibition of Bcl-۲, which is an important factor in tumor growth, along with the inhibition of apoptosis inhibitors Bcl-۲through venetoclax drug.RESALT: H-PCL NPs exhibited good physicochemical propertiesleading to efficient transfection of cancer cells and suppressionof target molecules. Moreover, combination therapysynergistically increased apoptosis, as well as decreased cellmigration, proliferation, , and angiogenesis in both HP-۱ andKG-۱ cell lines and suppressed cancer progression in luekemicbearingmice that was associated with enhanced survival time
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نویسندگان
Sevda Salimifard
Department of Hematology, Faculty of Medical Sciences, TarbiatModares University, Tehran, Iran
Sepideh Izadi
Immunology Research Center, Tabriz University of Medical Sciences,Tabriz, Iran
Hamed Mohammadi
Non-communicable Diseases Research Center, Alborz Universityof Medical Sciences, Karaj. Iran
AliAkbar Movassaghpour
Hematology and Oncology Research Center, Tabriz University ofMedical Sciences, Tabriz, Iran
Farhad Jadidi-Niaragh
Department of Immunology, Faculty of Medicine, Tabriz Universityof Medical Sciences, Tabriz, Iran
Saeid Kaviani Jabali
Department of Hematology, Faculty of Medical Sciences, TarbiatModares University, Tehran, Iran