Nanotechnology for Cancer Therapy; Systematicreview

Background: Nanotechnology has been gaining attention as apromising approach to cancer therapy due to its unique propertiesat the nanoscale. Nanoparticles can be engineered to specificallytarget cancer cells and deliver therapeutic agents directlyto the tumor site while minimizing toxicity to healthy tissues.Preclinical studies have shown promising results, and some nanotechnology-based cancer therapies have advanced to clinicaltrials. The most recent clinical findings in the use of nanotechnologyin cancer therapy were investigated in the present study.Materials and Methods: To investigate the most recent clinicalfindings on the use of nanotechnology in cancer therapy,a systematic review of published articles was conducted. Thestudy searched nine databases, including PubMed, Scopus, andGoogle Scholar, for relevant articles published between January۲۰۰۰ and January ۲۰۲۳. From the search results, ۲۰ articleswith complete abstracts were included in the study, and dataanalysis was performed using R version ۴.۲.۱ artificial intelligencesoftware.Results: The results of the study showed that nanotechnology has demonstrated promising results in cancer therapy research.Nanoparticles can be designed for targeted drug delivery, selectivelydelivering drugs to cancer cells while minimizing toxicityto healthy cells. Moreover, nanotechnology-based imagingtechniques offer high sensitivity and specificity, allowing forearlier detection and diagnosis of cancer. Additionally, combinationtherapy, where nanoparticles carry multiple therapeuticagents, has shown promise in preclinical studies and clinicaltrials. Nanoparticles can also be used to enhance the immuneresponse to cancer cells, either by delivering immunotherapeuticagents or by targeting immune cells to the tumor site.Conclusion: In Conclusion: , the potential of nanotechnologyto revolutionize cancer therapy by offering targeted drug delivery,enhanced imaging, combination therapy, and immunotherapyis promising. Designing nanoparticles to selectively targetcancer cells can increase drug efficacy while reducing toxicityto healthy cells. Nanotechnology has the potential to be a gamechangerin cancer therapy, and further research and clinical trialsare needed to fully realize its potential.

کلیدواژه ها:

Nanotechnology ، Cancer therapy ، Nanoparticles ، Drug delivery ، Tumor site