Guideline genetic tests for cancer diagnosis

Background: As treatment based genetic testing becomes a reality,it is important to assess the guideline genetic testing forcancer diagnosis. This guideline aims to provide an overviewof the various genetic tests available for cancer patients, theirappropriate timing, and their role in diagnosis and treatment.Genetic testing can help doctors personalize cancer treatmentby identifying specific genetic mutations that may influencedrug response and prognosis.Materials and Methods: Relevant articles were searched inPubmed, Google Scholar, and Web of Sciences using appropriatekeywords such as “genetic testing, cancer, diagnosis, guidelineand targeted therapy”.Results: Overall, according to the cancer type and family historywe can choose an appropriate diagnostic genetic test. Inindividuals with a strong family history or those with specificclinical criteria, germline genetic test can be selected in order toidentify inherited genetic mutation. This test can be done beforecancer develop or after cancer diagnosis to inform treatmentdecision and assess the risk of additional cancers. An anotheressential genetic test is somatic variant analysis. This test is carriedout after the diagnosis of cancer, preferably using a recentbiopsy. In this circumstances, if the mutated gene (s) is known,genetic mutation present only in the cancer cell will identify.While, if the mutated gene (s) is unknown, multiple genes simultaneouslywill analyze (Next-Generation-Sequencing). Resultsof this kind of test can guide targeted therapy decisionsand inform prognosis. In addition, pharmacogenetic testingshould be considered before initiating drug therapy, particularlyfor medications with known pharmacogenetic associations.This can help optimize drug selection and dosing.Conclusion: In Conclusion: , genetic testing plays a crucialrole in the diagnosis and treatment of cancer. By understandingthe various types of genetic tests available and their appropriatetiming, healthcare providers can optimize treatment decisionsand improve patient outcomes.

کلیدواژه ها:

genetic testing ، cancer ، diagnosis ، targeted therapy