Clinical significance of extended high-riskhuman papillomavirus genotyping in cervical cancer

Introduction: Cervical cancer is the fourth most common malignanttumor after breast cancer, colorectal cancer, and lungcancer, threating the health of women worldwide. It is wellknown that persistent human papillomavirus (HPV) infection isthe main risk factor for developing the disease. There are morethan ۲۰۰ HPV genotypes identified, but the most important inpublic health are the high-risk HPV genotypes including HPV۱۶, ۱۸, ۳۱, ۳۳, ۳۵, ۳۹, ۴۵, ۵۱, ۵۲, ۵۶, ۵۸,۵۹,۶۶ and ۶۸ due totheir strong association with cervical cancer. Among these,genotypes ۱۶ and ۱۸ are responsible for about ۷۰% of cervicalcancer cases worldwide.Materials and Methods: A systematic search has been carriedout for articles published in PubMed and Elsevier database byusing combi nations of different keywords with Boolean operators(AND, OR, NOT) including cervical cancer, HR-HPV, and Genotype.Results: HR-HPV genotypes have different distribution patternsin different countries and research populations. HPV-۵۲,HPV-۱۶, HPV-۵۸, and HPV-۱۸ are likely the most commonHPV genotypes in Asian countries.The widespread use of theHPV vaccine has changed the proportion of HPV-۱۶ and HPV-۱۸ infections in this population. Other HPV subtypes, such asHPV-۳۱, HPV-۳۳, HPV-۵۲, and HPV-۵۸, are more commonthan HPV-۱۸ in high-grade cervical lesions. In addition, HPV-۵۲ and HPV-۵۸ are also commonly occurring genotypes andhave a strong correlation with the occurrence and developmentof cervical cancer.Conclusion: This review concluded that cervical cancer screeningneeds to include extended HR-HPV genotyping. The examinationof extended HR-HPV genotyping in cervical intraepitheliallesions and cervical cancers can help guide clinical practices.

کلیدواژه ها:

HR-HPV ، Cervical cancer ، Genotype ، human papillomavirus