CD۲۴۷ As A Prognostic Marker in Head andNeck Squamous Cell Carcinoma: A Bioinformatic Analysis

Background: Head and neck squamous cell carcinoma (HNSC)is the seventh most frequent cancer. We can investigate possible molecular processes that can enhance the prognosis of HNSCpatients using The Cancer Genome Atlas (TCGA) large-scalesequencing-based genome analysis technologies.Materials and Methods: In this study, we used the TCGA libraryfor The HNSC RNA analysis and clinical data collection.We performed Univariate survival and differential expressionexperiments to obtain the overlapping gene set. By a proteinproteininteraction (PPI) analysis, module analysis, and GeneOntology (GO)/Kyoto Encyclopedia of Genes and Genomes(KEGG) functional enrichment analysis, we can find the hubgenes. Clinical association analysis and single and multivariateCox regression analyses on the discovered hub genes canidentify the predictive effect of hub genes on HNSC patients.Results: In all, we obtained ۶۰۱ intersecting gene sets. In amodular analysis, the highest-scoring module was ۱۹.۳۰۴.Based on the GO/KEGG enrichment analysis findings, theCD۲۴۷ molecule (CD۲۴۷) was finally known as the gene forthis investigation. The CD۲۴۷ was separated into a high-expressiongroup and a low-expression group. The Kaplan-Meiersurvival curve analysis demonstrated a significant differencebetween the two groups (P<۰.۰۰۰۱). The median survival timeof the low-expression CD۲۴۷ group was ۳۰.۹ months, and the۵-year survival rate was ۳۶.۴%. While the median survival timeof the high-expression CD۲۴۷ group was ۶۸.۸ months, and the۵-year survival rate was ۵۲.۳%. The clinical correlation studyindicated CD۲۴۷ was strongly adversely linked with pathologicaltumor stage and pathological nodal extracapsular dissemination.Gene Set Enrichment Analysis (GSEA) found CD۲۴۷activating KEGG pathways hsa۰۴۶۵۰ and hsa۰۴۶۶۰.Conclusion: CD۲۴۷ is a separate protective factor in the outcomeof HNSC patients. Activating the hsa۰۴۶۵۰ and hsa۰۴۶۶۰pathways boosted the production of interferon-gamma, interleukin(IL)-۲, and IL-۱۰, improving the tumor defense trackingability of the body, causing tumor cell apoptosis and slowingtumor cell growth. CD۲۴۷ is a possible target for enhancing thetreatment benefit of HNSC and the outlook of patients.

کلیدواژه ها:

CD۲۴۷ ، Head and Neck Squamous Cell Carcinoma(HNSC) ، Prognosis ، Bioinformatic Analysis ، PD-L۱