Clinicopathological Significance of CD۱۰۵ Expression in Squamous Cell Carcinoma of the Oral Cavity

Background: Angiogenesis is essential for the growth, invasion and metastasis of solid tumors. Research on related factors such as microvessel density can be helpful in predicting a tumor's behavior. CD۱۰۵ has been introduced as a marker of angiogenesis which stains vessels that are in the proliferating stage. There are some controversies about the relation of microvessel density and clinicopathological features of oral squamous cell carcinoma. The aim of this study is to determine the CD۱۰۵ expression in oral squamous cell carcinoma and its relation to the clinicopathological features of this disease.Methods: We studied a total of ۴۲ patients who had oral squamous cell carcinoma. The control group consisted of ۱۵ cases with normal oral epithelium. CD۱۰۵ immunostaining was performed on ۴ μm thick tissue sections. Intratumoral and peritumoral microvessel density in ten areas of the sections were recorded by two pathologists.Results: There was a significantly higher CD۱۰۵ microvessel density value in the tumoral tissues compared with normal tissues. In addition, there was more expression of this marker in the invasive front area. The CD۱۰۵ microvessel density value had a positive relation with lymph node metastasis. There was an association between tumor size and CD۱۰۵ microvessel density in the invasive front region. A negative association between tumor grade and CD۱۰۵ microvessel density value in the intratumoral region was observed. In both areas, CD۱۰۵ expression was higher in cases with advanced clinical stage. There was no association between this marker and patients' ages or gender.Conclusion: CD۱۰۵ microvessel density can be a useful factor for predicting the course of oral squamous cell carcinoma.