Wilms’ Tumor: Histopathological Variants and the Outcomes of ۳۱ Cases at a Tertiary Care Center in Northern India
محل انتشار: مجله سرطان خاورمیانه، دوره: 8، شماره: 3
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 54
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شناسه ملی سند علمی:
JR_MISJ-8-3_004
تاریخ نمایه سازی: 25 آبان 1402
چکیده مقاله:
Background: Wilms’ tumor is the most common malignant renal tumor in the pediatric age group. This tumor is classically managed by multimodal treatment which involves surgery, radiotherapy and chemotherapy. While there is plenty of data in world literature on the outcome of Wilms’ tumor, there is a paucity of data from India.Methods: All patients with proven diagnosis of Wilms’ tumor between ۲۰۰۸ to ۲۰۱۲ were noted from the hospital’s cancer registry. We performed detailed analyses of all patients’ clinical case records for demographic profiles, clinical features, imaging studies, treatment, and outcome. Histopathological classification of the tumor determined the patient’s post-operative management. All patients were followed for a period of ۳ years and we analyzed the eventual outcome in the form of disease-free survival, complications, tumor recurrence, and mortality.Results: There were ۳۱ cases of Wilms’ tumor included in this study. The median age of presentation was ۳-۴ years (range: ۵ months-۶ years) with a female: male ratio of ۱.۲:۱. Abdominal mass was the chief presenting feature in ۲۰ (۶۴.۵%) patients followed by abdominal pain in ۶ (۱۹.۳%). All children had unilateral disease, ۲۵ (۸۰.۶%) had right-sided and ۶ (۱۹.۳%) had left-sided disease. Bilateral disease was seen in only one case. Of the ۳۱ cases of Wilms’ tumor, ۳۶% cases presented with stages I and II disease, ۵۵% had stage III, and ۹% of the cases were stage IV. Most cases of Wilms’ tumor were stage III. The majority had classical Wilms’ tumor with a favourable histology. The estimated ۵-year event free survival was ۸۷.۳%Conclusion: A multidisciplinary approach can approach similar survival rates compared to the National Wilms’ Tumor Study Group, even in the Indian scenario. Further improvement in survival of these children can only be achieved by increasing awareness, early recognition, appropriate referral, and a multidisciplinary approach.
نویسندگان
Pradeep Kajal
Department of Pediatric Surgery, PGIMS Rohtak, Haryana, India
Kamal Rattan
Department of Pediatric Surgery, PGIMS Rohtak, Haryana, India
Namita Bhutani
Department of Pathology, PGIMS Rohtak, Haryana, India
Nisha Marwah
Department of Pathology, PGIMS Rohtak, Haryana, India