A Comparison of Endothelial Cell-Selective Adhesion Molecule and von Willebrand Factor Expression in Breast Cancer Growth and Metastasis
محل انتشار: مجله سرطان خاورمیانه، دوره: 9، شماره: 2
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 47
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شناسه ملی سند علمی:
JR_MISJ-9-2_002
تاریخ نمایه سازی: 25 آبان 1402
چکیده مقاله:
Background: Angiogenesis is the process of new blood vessels formation that contribute to tumor growth and metastasis. Endothelial cell-selective adhesion molecule is one of the proteins that expresses in vascular endothelial cells. In vitro and animal studies have shown involvement of this protein in physiological and pathological angiogenesis. von Willebrand factor is a protein expressed by endothelial cells and megakaryocytes that has a role in blood clotting processes. In the current study, we investigate the expression of endothelial cell-selective adhesion molecule and von Willebrand factor in carcinoma mammae specimens and explore their correlation with tumor growth and metastasis.Methods: We obtained ۷۹ specimens from paraffin blocks of patients diagnosed with invasive breast carcinoma of no special type. The slides from these specimens were then stained with endothelial cell-selective adhesion molecule, von Willebrand factor, and Ki-۶۷ antibodies to assess vascular numbers and cell proliferation.Results: We found a total of ۳۱ (۳۹%) low vascularity and ۴۸ (۶۱%) high vascularity samples from endothelial cell-selective adhesion molecule staining. There were ۳۴ (۴۳%) low vascularity and ۴۵ (۵۴%) high vascularity samples by von Willebrand factor staining. There was a significant correlation of blood vessel numbers in the endothelial cell-selective adhesion molecule-stained samples with tumor volume, metastasis to lymph nodes, and proliferation cells. The von Willebrand factor-expressed samples only had a significant correlation of vascular number with tumor volume.Conclusion: Endothelial cell-selective adhesion molecule and von Willebrand factor as the endothelial cell expressed proteins play a role in the angiogenesis process of breast cancer. However, endothelial cell-selective adhesion molecule expression is more consistent than von Willebrand factor in predicting the presence or absence of metastatic breast cancer.
نویسندگان
M Husni Cangara
Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Mochammad Hatta
Molecular Biology and Immunology Laboratory, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Upik Miskad
Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Syarifuddin Wahid
Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia