Prognostic Role of Epithelial Mesenchymal Transition Transcription Factors in Carcinoma- A Systematic Review and Meta-Analysis

Background: We conducted the present meta-analysis to delineate the prognostic significance of epithelial to mesenchymal transition- transcription factors in carcinoma patients. Method: For the determination of the pooled hazard ratio (HR) values based on the fixed- effects model, in this retrospective study, we employed comprehensive meta-analysis software. Results: This retrospective analysis identified the expression patterns of ۶۶۴۵ patients in ۳۶ studies. Expression of TWIST۱ correlated with the least prognosis rate (HR= ۲.۱۲۹, ۹۵% CI= ۱.۳۷۳ - ۳.۳۰۲) as compared to SNAIL۱ (HR= ۱.۸۰۴, ۹۵% CI= ۱.۱۵۱ - ۲.۸۲۷), SLUG (HR= ۱.۷۲۴, ۹۵% CI= ۰.۹۹۲ - ۲.۹۹۷) and ZEB۱ (HR= ۱.۵۹۰, ۹۵% CI= ۱.۳۵۸ - ۱.۸۶۱). Conclusion: These findings suggested the implication of TWIST۱ as an effective biomarker for an early tumor diagnosis and therapy for metastasis.

کلیدواژه ها:

Metastasis ، EMT-TFs ، Fixed effects model ، Cancer prognosis ، Biomarker