Immunohistochemistry-Based Molecular Subtyping of Breast Carcinoma in Industrial Population in India, Haryana: A Correlation with Clinicopathological Parameters
محل انتشار: مجله سرطان خاورمیانه، دوره: 12، شماره: 3
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 69
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شناسه ملی سند علمی:
JR_MISJ-12-3_005
تاریخ نمایه سازی: 25 آبان 1402
چکیده مقاله:
Background: Breast carcinoma is the most prevalent malignancy in females globally and also the leading cause of cancer-related mortality. The immunohistochemistry (IHC)-based molecular subtyping has put newer insights into the biological behaviour and clinical management of breast carcinoma. We conducted the present study to correlate the four IHC-based molecular subtypes: Luminal A, Luminal B, Human epidermal growth factor receptor ۲ positive, and triple negative breast carcinoma with various clinicopathological parameters amongst the industrial population of Haryana. Method: This cross-sectional study was conducted on ۹۲ cases of invasive breast carcinoma, who underwent modified radical mastectomy over a period of ۲.۵ years with the prior approval of Institutional Ethical Committee at ESIC Medical College and Hospital, Faridabad. We performed routine histopathological examination along with IHC (Estrogen receptor, Progesterone receptor and Human epidermal growth factor receptor ۲) study. The correlation of the four molecular subtypes with various clinicopathological parameters were also studied. We analysed the data using SPSS software. Results: The mean age of the patients in this study was ۴۷ years with a maximum number of cases in the ۳rd and ۴th decade of their life. The most common subtype was luminal B (۴۰.۹%) with the maximum number of cases presenting in stage II (۵۳.۲۶%) and with grade II (۵۱.۱%). Triple-negative breast cancer was found to be associated with brisk mitosis, lymphovascular invasion (۶۶.۶۷%), necrosis (۷۷.۷۸%), and ductal carcinoma in situ (۶۶.۶۷%). These findings were clinically significant. (P<۰.۰۵) Conclusion: The early age of presentation of breast carcinoma in the industrial population would warrant the need to focus on various molecular subtypes and clinicopathological parameters that may have different prognostic implications in this population.
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نویسندگان
Sujata Raychaudhuri
Department of Pathology, ESIC Medical College, Faridabad, Haryana, India
Akanksha Bajaj
Department of Pathology, ESIC Medical College, Faridabad, Haryana, India
Charu Agarwal
Department of Pathology, Alfalah Medical College, Faridabad, Haryana, India
Mukta Pujani
Department of Pathology, ESIC Medical College, Faridabad, Haryana, India
Kanika Singh
Department of Pathology, ESIC Medical College, Faridabad, Haryana, India
Varsha Chauhan
Department of Pathology, ESIC Medical College, Faridabad, Haryana, India
Ekta Gupta
Department of Community Medicine, ESIC Medical College, Faridabad, Haryana, India