Top ۱۰۰ Most Cited Publications on CTLA-۴ Molecule in Cancer Research: A Bibliometric Analysis

The aim of this research is to use bibliometric analysis to investigate the status and patterns of the ۱۰۰ most frequently cited publications regarding the cytotoxic Tlymphocyte- associated protein (CTLA-۴) research for cancer. The articles published on the topic were retrieved from the core collection database of Web of Science and PubMed using the Medical Subject Heading (MeSH) of “CTLA-۴” from ۱۹۸۶ to December ۶, ۲۰۲۰. The selected articles were examined and the bibliometric data compiled based on the number of citations, the author’s name, journal, publication year, institution, country, and co-occurrence keywords. ۴,۸۷۴ eligible papers were returned from the Web of Science Core Collection Database and PubMed. The citation frequency ranged from ۲۳۷۲ to ۲۰۵, with a median of ۴۶۰, and the top cited paper had ۲۳۷۲ citations. The journals with the most papers were Cell (n = ۸, ۳۵۴۱ citations, Impact Factor (IF) = ۴۱.۵۷۷) and Journal of Experimental Medicine (n = ۷, ۲۷۱۶ citations, IF = ۱۰.۷۹۰). Most of the published papers were from the United States of America (USA) (۴۱.۸%). A total of ۴۸۵ institutes and ۲۹ countries were involved in these ۱۰۰ articles. There were ۱۱۹۲ authors and the author with the highest number of papers was the Nobel Prize winner, Professor James P. Allison (۱۷ papers; ۸۷۰۰ citations). CTLA-۴ blockade was the most frequent keyword (۴۲.۱%), followed by metastatic melanoma (۴.۲۶%). This work presents an important bibliographic source and can be saved as a reference for future medical health research on the function of CTLA-۴ in cancer immunotherapy.

کلیدواژه ها:

bibliometric analysis ، CTLA-۴ Protein ، Cytotoxic T-Lymphocyte Antigen ۴ ، cancer ، immunotherapy