A Rare Entity: Papillary Thyroid Carcinoma with Squamous Differentiation Diagnosed in a Middle-aged Man Following Endoscopic Total Thyroidectomy via Axillo-Bilateral Breast Approach
محل انتشار: مجله سرطان خاورمیانه، دوره: 14، شماره: 1
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 33
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شناسه ملی سند علمی:
JR_MISJ-14-1_018
تاریخ نمایه سازی: 25 آبان 1402
چکیده مقاله:
Although squamous metaplasia is a well-known occurrence in papillary thyroid carcinoma (PTC), it is extremely uncommon to diagnose a PTC with squamous differentiation (PTC-SD), especially in a non-elderly patient, thus raising a diagnostic challenge when considering its broad histopathological differential diagnosis. Endoscopic thyroidectomy via axillo-bilateral breast approach (ABBA) has been recently validated as an appropriate surgical alternative to conventional thyroidectomy for treating PTC in the selected patients. Hereby, we report a rare case of PTC-SD diagnosed in a solitary thyroid nodule (STN) in a ۳۰-year-old man with a family history of thyroid cancer who was operated using the endoscopic ABBA. In fact, detection of the squamous cell carcinoma component may not be feasible through fine needle aspiration cytology or frozen section examinations, while permanent paraffin sections and immunohistochemistry (if required) usually allows for its identification. Due to their diverse clinical and biological behaviors, it is important to differentiate PTC-SD from other conditions in which a thyroid specimen contains a squamous epithelium. PTCSD patients with favorable clinicopathological criteria as young age and localized disease can be fortunate candidates for the minimally invasive thyroidectomy approaches as endoscopic ABBA.
کلیدواژه ها:
نویسندگان
Heba Sheta
Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Amal Abd El hafez
Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Dina Harb
Diagnostic and Interventional Radiology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Mohammad Zuhdy
Surgical Oncology Department, Oncology Center Mansoura University (OCMU), Faculty of Medicine, Mansoura University, Mansoura, Egypt
Islam Elzahaby
Surgical Oncology Department, Oncology Center Mansoura University (OCMU), Faculty of Medicine, Mansoura University, Mansoura, Egypt
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