Survival Analysis in Patients with Non- metastatic Squamous Cell Carcinoma of the Urinary Bladder
محل انتشار: مجله سرطان خاورمیانه، دوره: 2، شماره: 2
سال انتشار: 1390
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 114
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شناسه ملی سند علمی:
JR_MISJ-2-2_003
تاریخ نمایه سازی: 25 آبان 1402
چکیده مقاله Survival Analysis in Patients with Non- metastatic Squamous Cell Carcinoma of the Urinary Bladder
Background: We conducted a retrospective analysis to evaluate overall survival (OAS) and disease free survival (DFS) rates in patients with squamous cell carcinoma of the urinary bladder according to different prognostic factors.Methods: This retrospective study analyzed the medical records of patients with non-metastatic squamous cell carcinoma of the urinary bladder. All men underwent radical cystectomy and women underwent anterior pelvic exentration. Most patients had postoperative radiation therapy. The log-rank test examined differences in OAS and DFS rates.Results: The medical records of 106 patients were analyzed. The median follow- up from the date of enrollment was 30 months and ranged from 2 to 73 months. For the entire group, three-year OAS rates were 46.9% and DFS rates were 44%. For patients with P2 (tumor invasion into the muscularis propria) the three-year OAS rate was 53%, for P3 (tumor invasion into perivesical fat) it was 45% and 9% for P4 (tumor invasion into adjacent organs, pelvic wall or abdominal wall) The OAS rate was statistically significant in favor of P2 disease (P=0.0041). The three-year DFS rate was 50% for P2, 45% for P3 and 9% for P4 disease (P=0.0125). Administration of post-operative radiotherapy did not result in statistically significant improvement in three-year OAS and DFS rates.Conclusion: Survival rates were statistically significant and higher in patients with P2 and P3 disease compared to P4 disease. Adjuvant radiotherapy did not result in statistically significant survival improvement
نویسندگان مقاله Survival Analysis in Patients with Non- metastatic Squamous Cell Carcinoma of the Urinary Bladder
Mohamed El-Sayed
Radiation Therapy Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
Ahmed Abdel-Rahim
Urology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt