The Current Status of Pancreatic Cancer in Tunisia

سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 116

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شناسه ملی سند علمی:

JR_MISJ-11-3_006

تاریخ نمایه سازی: 25 آبان 1402

چکیده مقاله:

Background: Few studies have investigated pancreatic cancer in Tunisia and there are no reported survival data. The aim of this study was to analyze the epidemiologic profile, treatment modalities, and survival and prognostic factors of patients with pancreatic cancer in Tunisia. Method: In this retrospective study, we included patients treated between ۲۰۰۱ and ۲۰۱۶ for a histologically proven pancreatic cancer in the Department of Medical Oncology in Tunisia. Results: We examined ۱۳۰ patients with a median age of ۵۸.۷ years and a sex ratio of ۱.۸. Thirty percent had surgery for a localized disease. Among resected patients, ۱۴% received adjuvant chemotherapy. ۱۴.۵% of the patients with borderline resectable tumors underwent induction chemotherapy without leading to surgery. Palliative chemotherapy was administrated for unresectable locally advanced (۱۴%) and metastatic (۴۱.۵%) tumors. Median overall survival for localized, locally advanced, and metastatic disease was ۲۰.۵, ۱۰.۴, and ۶.۳ months, respectively. Independent prognostic factors were female gender, performance status, tumor localization, and chemotherapy. Conclusions: Unlike what was published in the literature, patients in our study were younger and there was a male predominance. Survival rates were low even for localized stages. Treatment strategy, chemotherapy protocols, survival, and prognostic factors were in line with the literature.

نویسندگان

Imtinene Belaid

Université de Sousse, Faculté de Médecine de Sousse, Department of Medical Oncology, Farhat Hached Hospital, Sousse, Tunisia

Wiem Khechine

Université de Sousse, Faculté de Médecine de Sousse, Department of Familial and Community, Medicine, Sousse, Tunisia

Manel Limame

Université de Sousse, Faculté de Médecine de Sousse, Department of Familial and Community, Medicine, Sousse, Tunisia

Jihene Sahli

Université de Sousse, Faculté de Médecine de Sousse, Department of Familial and Community, Medicine, Sousse, Tunisia

Mohamed Amine Elghali

Université de Sousse, Faculté de Médecine de Sousse, Department of Surgery, Farhat Hached Hospital, Sousse, Tunisia

Faten Ezzairi

Université de Sousse, Faculté de Médecine de Sousse, Department of Medical Oncology, Farhat Hached Hospital, Sousse, Tunisia

Makrem Hochlaf

Université de Sousse, Faculté de Médecine de Sousse, Department of Medical Oncology, Farhat Hached Hospital, Sousse, Tunisia

Imene Chabchoub

Université de Sousse, Faculté de Médecine de Sousse, Department of Medical Oncology, Farhat Hached Hospital, Sousse, Tunisia

Leila Ben Fatma

Université de Sousse, Faculté de Médecine de Sousse, Department of Medical Oncology, Farhat Hached Hospital, Sousse, Tunisia

Mohamed Ben Mabrouk

Université de Sousse, Faculté de Médecine de Sousse, Department of Surgery, Sahloul Hospital, Sousse, Tunisia

Rached Letaief

Université de Sousse, Faculté de Médecine de Sousse, Department of Surgery, Farhat Hached Hospital, Sousse, Tunisia

Ali Ben Ali

Université de Sousse, Faculté de Médecine de Sousse, Department of Surgery, Sahloul Hospital, Sousse, Tunisia

Slim Ben Ahmed

Université de Sousse, Faculté de Médecine de Sousse, Department of Medical Oncology, Farhat Hached Hospital, Sousse, Tunisia